2,243 research outputs found
Models of atypical development must also be models of normal development
Functional magnetic resonance imaging studies of developmental disorders and normal cognition that include children are becoming increasingly common and represent part of a newly expanding field of developmental cognitive neuroscience. These studies have illustrated the importance of the process of development in understanding brain mechanisms underlying cognition and including children ill the study of the etiology of developmental disorders
Analytical assessment of mine water rebound. Case study Ruhr coal basin
This study aims to assess key factors that influence mine water rebound on the example of a large amount of hard coal mines flooded or being flooded in Europe. Three German mines have been selected for a detailed study. A mathematical model based on analytical formulae of seepage theory has been employed to calculate time-dependent radial inflow to the shaft simulated as a big well in vertically heterogeneous rocks. The results of modelling showed good conformity with measurements for all studied mines. Besides, we evaluated the sensitivity of the model output to parameter variations for mine water level and initial inflow to the mine
Permafrost - physical aspects and carbon cycling, databases and uncertainties
Permafrost is defined as ground that remains below 0°C for at least 2 consecutive years. About 24% of the northern hemisphere land area is underlain by permafrost. The thawing of permafrost has the potential to influence the climate system through the release of carbon (C) from northern high latitude terrestrial ecosystems, but there is substantial uncertainty about the sensitivity of the C cycle to thawing permafrost. Soil C can be mobilized from permafrost in response to changes in air temperature, directional changes in water balance, fire, thermokarst, and flooding. Observation networks need to be implemented to understand responses of
permafrost and C at a range of temporal and spatial scales. The understanding gained from these observation networks needs to be integrated into modeling frameworks capable of representing how the responses of permafrost C will influence the trajectory of climate in the future
Explaining Legal Concepts with Augmented Large Language Models (GPT-4)
Interpreting the meaning of legal open-textured terms is a key task of legal
professionals. An important source for this interpretation is how the term was
applied in previous court cases. In this paper, we evaluate the performance of
GPT-4 in generating factually accurate, clear and relevant explanations of
terms in legislation. We compare the performance of a baseline setup, where
GPT-4 is directly asked to explain a legal term, to an augmented approach,
where a legal information retrieval module is used to provide relevant context
to the model, in the form of sentences from case law. We found that the direct
application of GPT-4 yields explanations that appear to be of very high quality
on their surface. However, detailed analysis uncovered limitations in terms of
the factual accuracy of the explanations. Further, we found that the
augmentation leads to improved quality, and appears to eliminate the issue of
hallucination, where models invent incorrect statements. These findings open
the door to the building of systems that can autonomously retrieve relevant
sentences from case law and condense them into a useful explanation for legal
scholars, educators or practicing lawyers alike
Rubber friction: role of the flash temperature
When a rubber block is sliding on a hard rough substrate, the substrate
asperities will exert time-dependent deformations of the rubber surface
resulting in viscoelastic energy dissipation in the rubber, which gives a
contribution to the sliding friction. Most surfaces of solids have roughness on
many different length scales, and when calculating the friction force it is
necessary to include the viscoelastic deformations on all length scales. The
energy dissipation will result in local heating of the rubber. Since the
viscoelastic properties of rubber-like materials are extremely strongly
temperature dependent, it is necessary to include the local temperature
increase in the analysis. At very low sliding velocity the temperature increase
is negligible because of heat diffusion, but already for velocities of order
0.01 m/s the local heating may be very important. Here I study the influence of
the local heating on the rubber friction, and I show that in a typical case the
temperature increase results in a decrease in rubber friction with increasing
sliding velocity for v > 0.01 m/s. This may result in stick-slip instabilities,
and is of crucial importance in many practical applications, e.g., for the
tire-road friction, and in particular for ABS-breaking systems.Comment: 22 pages, 27 figure
Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy
Objective: Diabetic cardiomyopathy is associated with increased mortality in patients with diabetes mellitus. The underlying pathology of this disease is still under discussion. We studied the role of the kinin B1 receptor on the development of experimental diabetic cardiomyopathy. Research Design and Methods: We utilized B1 receptor knockout mice and investiged cardiac inflammation, fibrosis and oxidative stress after induction of streptozotocin (STZ)-induced diabetes mellitus. Furthermore, the left ventricular function was measured by pressure-volume loops after 8 weeks of diabetes mellitus. Results: B1 receptor knockout mice showed an attenuation of diabetic cardiomyopathy with improved systolic and diastolic function in comparison with diabetic control mice. This was associated with a decreased activation state of the MAP kinase p38, less oxidative stress as well as normalized cardiac inflammation, shown by fewer invading cells and, no increase in matrix metalloproteinase-9 as well as the chemokine CXCL-5. Furthermore, the pro-fibrotic connective tissue growth factor was normalized, leading to a reduction in cardiac fibrosis despite severe hyperglycemia in mice lacking the B1 receptor. Conclusion: These findings suggest that the B1 receptor is detrimental in diabetic cardiomyopathy in that it mediates inflammatory and fibrotic processes. These insights might have useful implications on future studies utilizing B1 receptor antagonists for treatment of human diabetic cardiomyopathy
Water management practices: Irrigated Cropland
Irrigation is practiced on about 17 percent of
the world's arable land. Irrigated land accounts
for 33 percent of the world's food production
(FAO, 1988) and contributes greatly to the economy
in many agricultural regions. In developing
countries, nearly 60 percent of rice and wheat
production used for food is grown on irrigated
cropland. The United Nation's Food and Agriculture
Organization (1988) estimates that about
two-thirds of the increase in arable land needed
to produce food crops by 2050 will be irrigated.
Along with the significant economic impact of
irrigated agriculture, however, come significant
environmental and natural resource impacts.
U.S. Department of Agriculture (USDA)
conservation programs commonly are used to
improve irrigation systems and their management
in an attempt to reduce the impacts of irrigation
on the environment and natural resources
The Geoff Egan Memorial Lecture 2011. Artefacts, art and artifice: reconsidering iconographic sources for archaeological objects in early modern Europe
A first systematic analysis of historic domestic material culture depicted in contemporaneous Western painting and prints, c.1400-1800. Drawing on an extensive data set, the paper proposes to methodologies and hermeneutics for historical analysis and archaeological correspondence
- …